SEEI: spherical evolution with feedback mechanism for identifying epistatic interactions.

ABSTRACT:

Background

Detecting epistatic interactions (EIs) involves the exploration of associations among single nucleotide polymorphisms (SNPs) and complex diseases, which is an important task in genome-wide association studies. The EI detection problem is dependent on epistasis models and corresponding optimization methods. Although various models and methods have been proposed to detect EIs, identifying EIs efficiently and accurately is still a challenge.

Results

Here, we propose a linear mixed statistical epistasis model (LMSE) and a spherical evolution approach with a feedback mechanism (named SEEI). The LMSE model expands the existing single epistasis models such as LR-Score, K2-Score, Mutual information, and Gini index. The SEEI includes an adaptive spherical search strategy a

SUBMITTER: Tang DY 

PROVIDER: S-EPMC11633023 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature