Physiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF.

ABSTRACT:

Background

Prone positioning (PP) improves oxygenation in awake patients with acute hypoxemic respiratory failure (AHRF). However, the underlying mechanisms remain unclear in patients with diverse lung morphology. We aimed to determine the short-term effects of awake prone positioning (APP) in AHRF patients with focal and non-focal lung morphology.

Methods

This is a prospective physiological study. Twenty-four non-intubated patients with PaO₂/FiO₂ ≤ 300 mm Hg were included. Gas exchange, ventilation and perfusion distribution, and hemodynamics variables were recorded in the supine position (SP1), 2 h after PP, and 1 h after re-supine (SP2). Lung morphology was classified as focal and non-focal patterns using computed tomography.

Results

Twelve of

SUBMITTER: Chao Y 

PROVIDER: S-EPMC11633027 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature