Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseases.

ABSTRACT:

Background

Dysfunctional processes in Alzheimer's disease and other neurodegenerative diseases lead to neural degeneration in the central and peripheral nervous system. Research demonstrates that neurodegeneration of any kind is a systemic disease that may even begin outside of the region vulnerable to the disease. Neurodegenerative diseases are defined by the vulnerabilities and pathology occurring in the regions affected.

Method

A random forest machine learning analysis on whole blood transcriptomes from six neurodegenerative diseases generated unbiased disease-classifying RNA transcripts subsequently subjected to pathway analysis.

Results

We report that transcripts of the blood transcriptome selected for each of the neurodegenerative diseases represent fundamental

SUBMITTER: Huseby CJ 

PROVIDER: S-EPMC11633037 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature