Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8⁺ T cell responses against an arthritogenic alphavirus.

ABSTRACT: Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8⁺ T-cell responses. Here, we used a recombinant RRV-gp33 that expresses the immunodominant CD8⁺ T-cell epitope of lymphocytic choriomeningitis virus (LCMV) to directly compare responses with a virus, LCMV, that strongly induces antiviral CD8⁺ T cells. After footpad injection, we detected fewer gp33-specific CD8⁺ T cells in the draining lymph node (DLN) after RRV-gp33 than LCMV infection, despite similar viral RNA levels in the foot. However, less RRV RNA was detected in the DLN compared to LCMV, with RRV localizing principally to the subcapsular regio

SUBMITTER: Bullock CB 

PROVIDER: S-EPMC11633147 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature