An orphan kinesin in <i>Trypanosoma brucei</i> regulates hook complex assembly and Golgi biogenesis.

ABSTRACT: Kinesins are microtubule-based motor proteins that play diverse cellular functions by regulating microtubule dynamics and intracellular transport in eukaryotes. The early branching kinetoplastid protozoan Trypanosoma brucei has an expanded repertoire of kinetoplastid-specific kinesins and orphan kinesins, many of which have unknown functions. We report here the identification of an orphan kinesin named KIN-G that plays an essential role in maintaining hook complex integrity and promoting Golgi biogenesis in T. brucei. KIN-G localizes to the distal portion of the centrin arm of the flagellum-associated hook complex through association with the centrin arm protein TbCentrin4. Knockdown of KIN-G in T. brucei disrupts the integrity of the hook complex by reducing the lengt

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC11633155 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature