Trehalose polyphleates participate in <i>Mycobacterium abscessus</i> fitness and pathogenesis.

ABSTRACT: Mycobacteria produce a large repertoire of surface-exposed lipids with major biological functions. Among these lipids, trehalose polyphleates (TPPs) are instrumental in the infection of Mycobacterium abscessus by the therapeutic phage BPs. However, while the biosynthesis and transport of TPPs across the membrane by MmpL10 have been reported, the role of TPPs in host infection remains enigmatic. Here, we addressed whether the loss of TPPs influences interactions with macrophages and the virulence of M. abscessus. As anticipated, the deletion of mmpL10 in smooth (S) and rough (R) variants of M. abscessus abrogated TPP production, which was rescued upon gene complementation. Importantly, infection of human THP-1 cells with the mmpL10 mutants was associated w

SUBMITTER: Malmsheimer S 

PROVIDER: S-EPMC11633156 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature