Infant feces-derived <i>Lactobacillus gasseri</i> FWJL-4 mitigates experimental necrotizing enterocolitis <i>via</i> acetate production.

ABSTRACT: Necrotizing enterocolitis (NEC) is a life-threatening disease in premature infants, characterized by high mortality. Recent studies increasingly highlight the role of gut dysbiosis in NEC pathogenesis. Although probiotics have shown some efficacy in preventing NEC, further research is needed to determine potential strains and approaches. In this study, we demonstrated that the novel probiotic strain Lactobacillus gasseri (L. gasseri) FWJL-4, isolated from the feces of healthy infants, significantly enhanced intestinal barrier function, providing substantial protection against NEC. This protective effect was attributed to elevated intestinal acetate levels. Notably, acetate supplementation alone was sufficient to mitigate NEC, mimicking the protective effects of L. gasseri<

SUBMITTER: Pan LL 

PROVIDER: S-EPMC11633162 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature