Follistatin like-1 (<i>Fstl1</i>) regulates adipose tissue development in zebrafish.

ABSTRACT: Obesity is a highly prevalent disorder with complex aetiology. Therefore, studying its associated cellular and molecular pathways may be aided by analysing genetic tractable diseases. In this context, the study of ciliopathies such as Bardet-Biedl syndrome has highlighted the relevance of primary cilia in obesity, both in the central nervous system and peripheral tissues. Based on our previous in vitro results supporting the role of a novel Bbs4-cilia-Fstl1 axis in adipocyte differentiation, we evaluated the in vivo relevance of the zebrafish orthologous genes fstl1a and fstl1b in primary cilia and adipose tissue development. Using a combination of knockdowns and a new fstl1a mutant line, we show that fstl1a promotes primary cilia formation in earl

SUBMITTER: Guggeri L 

PROVIDER: S-EPMC11633180 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature