A genetic and proteomic comparison of key AD biomarkers across tissues.

ABSTRACT:

Introduction

Plasma has been proposed as an alternative to cerebrospinal fluid (CSF) for measuring Alzheimer's disease (AD) biomarkers, but no studies have analyzed in detail which biofluid is more informative for genetics studies of AD.

Method

Eleven proteins associated with AD (α-synuclein, apolipoprotein E [apoE], CLU, GFAP, GRN, NfL, NRGN, SNAP-25, TREM2, VILIP-1, YKL-40) were assessed in plasma (n = 2317) and CSF (n = 3107). Both plasma and CSF genome-wide association study (GWAS) analyses were performed for each protein, followed by functional annotation. Additional characterization for each biomarker included calculation of correlations and predictive power.

Results

Eighteen plasma protein quantitative train loci (pQTLs) associated with 10 proteins and 16 CSF p

SUBMITTER: Marsh TW 

PROVIDER: S-EPMC11633343 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature