Blood-based multivariate methylation risk score for cognitive impairment and dementia.

ABSTRACT:

Introduction

The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator of lifestyle and environmental influences, positions blood-derived DNA methylation as a promising tool for early dementia risk detection.

Methods

In conjunction with an extensive array of machine learning techniques, we employed whole blood genome-wide DNA methylation data as a surrogate for 14 modifiable and non-modifiable factors in the assessment of dementia risk in independent dementia cohorts.

Results

We established a multivariate methylation risk score (MMRS) for identifying mild cognitive impairment cross-sectionally, independent of age and sex (P = 2.0 × 10^-3). This score significantly predicted the prospec

SUBMITTER: Koetsier J 

PROVIDER: S-EPMC11633365 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature