Evolutionary trajectories of β-lactam resistance in <i>Enterococcus faecalis</i> strains.

ABSTRACT: Resistance to ampicillin and imipenem in Enterococcus faecalis is infrequent. However, the evolution of resistance can occur through prolonged antibiotic exposure during the treatment of chronic infections. In this study, we conducted a long-term evolution experiment using four genetically diverse strains of E. faecalis with varying susceptibilities to ampicillin and imipenem. Each strain was subjected to increasing concentrations of either ampicillin or imipenem over 200 days, with three independent replicates for each strain. Selective pressure from imipenem led to the rapid selection of highly resistant lineages across all genetic backgrounds, compared to ampicillin. In addition to high resistance, we describe, for the first time, the evolution of a β-lactam-dependent phen

SUBMITTER: Ugalde Silva P 

PROVIDER: S-EPMC11633384 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature