Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population.

ABSTRACT:

Purpose

The present study evaluated the sensitivity and specificity of important proteomic salivary biomarkers; IL-6, IL-8, and sCD44 in the early detection of oral cancer, and any possible associations with risk factors of oral cancer in an Egyptian population.

Methods

The present investigation was conducted on 100 individuals; 25 healthy controls, 25 patients having oral potentially malignant disorders (OPMDs) with dysplasia; 25 patients having OPMDs without dysplasia, and 25 oral cancer patients. Demographic data modified gingival index, oral hygiene level, and salivary levels of the biomarkers were assessed.

Results

Salivary levels of IL-6, IL-8, and sCD44 progressively increased with increased disease severity. Salivary IL-8 and IL-6 levels possess a discriminati

SUBMITTER: Ghalwash D 

PROVIDER: S-EPMC11633404 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature