Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial.

ABSTRACT:

Background

Synbiotics, combining specific probiotics and selected prebiotics, may benefit health issues like obesity, but evidence remains inconsistent.

Objective

This study aimed to verify the effect of a pre-screened synbiotics combination [containing Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup), galacto-oligosaccharides (GOS) and xylo-oligosaccharides (XOS)] on obesity in the population.

Methods

In a randomized, double-blind, placebo-controlled trial, 80 individuals with obesity consumed daily synbiotics (containing MN-Gup 1 × 10¹¹ CFU/day, GOS 0.7 g/day, and XOS 0.7 g/day) or placebo for 12 weeks. Body composition, blood lipids, serum hormone, bile acids, and gut microbiota were measured pre-and post-intervention.

Results

SUBMITTER: Niu X 

PROVIDER: S-EPMC11633458 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature