Systemic lupus erythematosus and epilepsy: A Mendelian randomization study.

ABSTRACT:

Objective

Numerous observational studies have found a relationship between systemic lupus erythematosus (SLE) and epilepsy; however, their causal relationship remains unclear. This study aimed to investigate the causal role of SLE in epilepsy or any of its subtypes using a two-sample Mendelian randomization (MR) analysis.

Methods

Single nucleotide polymorphisms (SNPs) linked to SLE were utilized as instrumental variables in MR analysis to assess their causal impact on epilepsy. The primary MR findings were derived using the inverse variance weighted (IVW) method, which was further supported by the weighted median and MR-Egger regression techniques. Additionally, sensitivity analyses, including Cochran's Q test and pleiotropy tests, were conducted to evaluate the influence of

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11633673 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature