Treatment with brivaracetam has no apparent long-term effects on body weight in pediatric patients with epilepsy.

ABSTRACT:

Objective

The objective of this study is to evaluate possible long-term effects of treatment with brivaracetam (BRV) on body weight in children with epilepsy.

Method

Post hoc analysis of data from patients (aged 1 month to <17 years) with ≥6 months of BRV treatment in a long-term, open-label trial (N01266 [NCT01364597]). Outcomes included body weight and body mass index (BMI) over time (z-score growth curves), and treatment-emergent adverse events (TEAEs). Previous/ongoing medical conditions that may affect body weight (gastrointestinal and metabolic/nutritional disorders); concomitant antiseizure medications (ASMs) were also evaluated.

Results

Two hundred nine patients (mean [standard deviation] age 7.9 [4.6] years) were analyzed. Most (154 [73.7%]) had focal-onset s

SUBMITTER: Floricel FI 

PROVIDER: S-EPMC11633704 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature