Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing.

ABSTRACT:

Objective

Dystonic posturing (DP) is a common semiology in temporal lobe epilepsy (TLE). We aimed to explore cerebellar gradient alterations in functional connectivity in TLE patients with and without DP.

Methods

Resting-state functional MRI data were obtained in 60 TLE patients and 32 matched healthy controls. Patients were further divided into two groups: TLE with DP (TLE + DP, 31 patients) and TLE without DP (TLP-DP, 29 patients). We explored functional gradient alterations in the cerebellum based on cerebellar-cerebral functional connectivity and combined with independent component analysis to evaluate cerebellar-cerebral functional integration and reveal the contribution of the motor components to the gradient.

Results

There were no obvious differences in clinica

SUBMITTER: Li W 

PROVIDER: S-EPMC11633717 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature