Ketosis regulates K⁺ ion channels, strengthening brain-wide signaling disrupted by age.

ABSTRACT: Aging is associated with impaired signaling between brain regions when measured using resting-state fMRI. This age-related destabilization and desynchronization of brain networks reverses itself when the brain switches from metabolizing glucose to ketones. Here, we probe the mechanistic basis for these effects. First, we confirmed their robustness across measurement modalities using two datasets acquired from resting-state EEG (Lifespan: standard diet, 20-80 years, N = 201; Metabolic: individually weight-dosed and calorically-matched glucose and ketone ester challenge, μage=26.9±11.2years , N = 36). Then, using a multiscale conductance-based neural mass model, we identified the unique set of mechanistic parameters consistent with our clinical data. Together, our results impli

SUBMITTER: van Nieuwenhuizen H 

PROVIDER: S-EPMC11633768 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature