Evaluation of the cervical liquid-based cytology sample as a microbiome resource for dual diagnosis.

ABSTRACT: Cervical cancer, which is mainly caused by oncogenic human papillomavirus subtypes, remains a significant global health challenge. Recent studies have indicated a connection between cervical cancer and the uterine microbiome, underscoring its importance. This study explored the potential of liquid-based cytology (LBC) samples, which are typically used for cytological analysis, in investigating the cervical microbiome. Thirty women participated in the study and provided clinical information. Three samples were obtained from each participant: one for clinical purposes using LBC, another for microbiome sampling using LBC, and a third using the SWAB Microbiome kit. The LBC and traditional swab (SWAB) samples were subjected to high-throughput 16S rRNA gene sequencing for microbiome analysis. Th

SUBMITTER: Lim C 

PROVIDER: S-EPMC11633947 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature