Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens.

ABSTRACT: Interspecies interactions involving direct competition via bacteriocin production play a vital role in shaping ecological dynamics within microbial ecosystems. For instance, the ribosomally produced siderophore bacteriocins, known as class IIb microcins, affect the colonization of host-associated pathogenic Enterobacteriaceae species. Notably, to date, only five of these antimicrobials have been identified, all derived from specific Escherichia coli and Klebsiella pneumoniae strains. We hypothesized that class IIb microcin production extends beyond these specific compounds and organisms. With a customized informatics-driven approach, screening bacterial genomes in public databases with BLAST and manual curation, we have discovered 12 previously unknown class IIb

SUBMITTER: Mortzfeld BM 

PROVIDER: S-EPMC11634061 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature