Dynamic gene expression pattern in zebrafish gall bladder - an experimental study.

ABSTRACT: Gall bladder cancer (GBC) is one of the common biliary tract malignancies that is often associated with late presentation of clinical symptoms resulting in poor prognosis, thereby considerably increasing the mortality rate. Geographic and ethnic variations are one of the major causes of GBC incidence. However, in addition to genetic susceptibility to GBC, other factors like age, obesity, gender, and exposure to certain heavy chemicals may also lead to the incidence of GBC. Most of GBC research has so far used traditional cell culture systems. Recently, newer approaches using 2D and 3D cultures, xenograft models, and organoids are also becoming popular. However, whole organism model systems for GBC research have not yet been established. In this study, we propose the use of zebrafish as a m

SUBMITTER: Tanwar P 

PROVIDER: S-EPMC11634144 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature