Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.

ABSTRACT: The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D₃ (1,25D₃) regulates epidermal stem cell fate, such that VDR removal from Krt14 expressing keratinocytes delays re-epithelialization of epidermis after wound injury in mice. In this study we deleted Vdr from Lrig1 expressing stem cells in the isthmus of the hair follicle then used lineage tracing to evaluate the impact on re-epithelialization following injury. We showed that Vdr deletion from these cells prevents their migration to and regeneration of the interfollicular epidermis without impairing their ability to repopulate the sebaceous gland. To pursue the molecular basis for these effects of VDR, we performed genome wide transcriptional analysis of keratinocytes from Vdr cKO and control littermate mic

SUBMITTER: Oda Y 

PROVIDER: S-EPMC11634282 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature