Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936.

ABSTRACT:

Background

Air pollution in later life has been associated with dementia; however, limited research has investigated the association between air pollution across the life course, either at specific life periods or cumulatively. The project investigates the association of air pollution with dementia via a life-course epidemiological approach.

Methods

Participants of the Lothian Birth Cohort, born in 1936, provided lifetime residential history in 2014. Participant's air pollution exposure for time periods 1935, 1950, 1970, 1980, 1990, 2001, and 2007 was modeled using an atmospheric chemistry transport model. Lifetime cumulative exposures were calculated as time-weighted mean exposure. Of 572 participants, 67 developed all-cause dementia [35 with Alzheimer's dementia (AD)] by w

SUBMITTER: Jutila OI 

PROVIDER: S-EPMC11634326 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature