Fat Grafting and Adipose Stem Cells for Facial Systemic Sclerosis: A Systematic Review of the Literature.

ABSTRACT:

Background

Orofacial modifications occurring in systemic sclerosis are detrimental for patients, but the therapeutic options are limited.

Objectives

This systematic review aimed to perform an up-to-date appraisal of the literature focusing on fat grafting and other adipose stem cell-based therapies for the treatment of facial systemic sclerosis, determining its efficacy and safety, and investigating the current practice for treatment optimization.

Methods

The review was prospectively registered in PROSPERO (CRD42021286268) and followed the PRISMA principles. Multiple databases were searched and only original studies were included.

Results

Over the 12 studies matching the inclusion criteria, 174 patients were treated. Of these, 87.3% (n = 152) were considered to

SUBMITTER: Almadori A 

PROVIDER: S-EPMC11634384 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature