LRRK2^G2019S Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

ABSTRACT:

Background

While the gradually aggravated motor and non-motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine-rich repeat kinase2 (LRRK2) is a common disease-causing gene in PD. Little is known about its role in skeletal muscle impairment and its underlying mechanisms.

Methods

To investigate whether the mutation in LRRK2 causes skeletal muscle impairment, we used 3-month-old (3mo) and 14-month-old (14mo) LRRK2^G2019S transgenic (TG) mice as a model of PD, compared with the age-matched littermate wild-type (WT) controls. We measured the muscle mass and strength, ultrastructure, inflammatory infiltration, mitochondrial morphology and dynamics dysfunctio

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11634472 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature