Tensile force impairs lip muscle regeneration under the regulation of interleukin-10.

ABSTRACT:

Background

Orbicularis oris muscle, the crucial muscle in speaking, facial expression and aesthetics, is considered the driving force for optimal lip repair. Impaired muscle regeneration remains the main culprit for unsatisfactory surgical outcomes. However, there is a lack of study on how different surgical manipulations affect lip muscle regeneration, limiting efforts to seek effective interventions.

Methods

In this study, we established a rat lip surgery model where the orbicularis oris muscle was injured by manipulations including dissection, transection and stretch. The effect of each technique on muscle regeneration was examined by histological analysis of myogenesis and fibrogenesis. The impact of tensile force was further investigated by the in vitro application of m

SUBMITTER: Cheng X 

PROVIDER: S-EPMC11634486 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature