Sphingolipid metabolites as potential circulating biomarkers for sarcopenia in men.

ABSTRACT:

Background

Sarcopenia is an age-related progressive loss of muscle mass and function. Sarcopenia is a multifactorial disorder, including metabolic disturbance; therefore, metabolites may be used as circulating biomarkers for sarcopenia. We aimed to investigate potential biomarkers of sarcopenia using metabolomics.

Methods

After non-targeted metabolome profiling of plasma from mice of an aging mouse model of sarcopenia, sphingolipid metabolites and muscle cells from the animal model were evaluated using targeted metabolome profiling. The associations between sphingolipid metabolites identified from mouse and cell studies and sarcopenia status were assessed in men in an age-matched discovery (72 cases and 72 controls) and validation (36 cases and 128 controls) cohort; women wi

SUBMITTER: Seo JH 

PROVIDER: S-EPMC11634516 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature