Trajectories of adherence to intravenous biological treatment in patients with inflammatory bowel disease: a longitudinal analysis.

ABSTRACT:

Background

Long-term biological therapies for inflammatory bowel disease (IBD) include infliximab and vedolizumab, which are administered intravenously. Although highly effective, non-adherence to these biologics is common and is associated with adverse sequelae and loss of response.

Objective

In this study, we aim to characterize long-term intravenous biologic adherence trajectories among IBD patients and identify the factors linked with these trajectories.

Methods

We conducted a retrospective multicenter study of IBD patients over 2 years to assess their adherence to infliximab and vedolizumab. The date of infusion was determined based on medical and pharmacy records. Using group-based trajectory modeling (GBTM), adherence trajectories were identified based on patie

SUBMITTER: Dong X 

PROVIDER: S-EPMC11634588 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature