Epilepsy is associated with the accelerated aging of brain activity in sleep.

ABSTRACT:

Objective

Although seizures are the cardinal feature, epilepsy is associated with other forms of brain dysfunction including impaired cognition, abnormal sleep, and increased risk of developing dementia. We hypothesized that, given the widespread neurologic dysfunction caused by epilepsy, accelerated brain aging would be seen. We measured the sleep-based brain age index (BAI) in a diverse group of patients with epilepsy. The BAI is a machine learning-based biomarker that measures how much the brain activity of a person during overnight sleep deviates from chronological age-based norms.

Methods

This case-control study drew information of age-matched controls without epilepsy from home sleep monitoring volunteers and from non-epilepsy patients with Sleep Lab testing. Patients

SUBMITTER: Hadar PN 

PROVIDER: S-EPMC11634596 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature