Outer Retinal Thinning is Associated With Brain Atrophy in Early Age-Related Macular Degeneration.

ABSTRACT:

Purpose

Both retinal changes and age-related macular degeneration (AMD) have been shown to be associated with Alzheimer's disease and related dementias (ADRD). In AMD, the outer retina is impacted significantly and early, but little is known about its association with cognition or changes in brain morphometry. This study investigates the relationship between retinal and brain morphometry in older adults with early and intermediate AMD.

Design

Cross-sectional study.

Methods

Adults ≥70 years with normal, early, and intermediate AMD were recruited from Callahan Eye Hospital Clinics at the University of Alabama at Birmingham. Participants underwent cognitive testing, optical coherence tomography, and magnetic resonance imaging. Associations of retinal layer thickness with

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11634662 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature