Single-cell transcriptomic atlas of taste papilla aging.

ABSTRACT: Taste perception is one of the important senses in mammals. Taste dysfunction causes significant inconvenience in daily life, leading to subhealth and even life-threatening condition. Aging is a major cause to taste dysfunction, while the underlying feature related to gustatory aging is still not known. Using single-cell RNA Sequencing, differentially expressed genes between aged and young taste papillae are identified, including upregulated mt-Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. In the Tmem59^-/- circumvallate papillae (CVP), taste mature cell generation is impaired by reduction in the numbers of PLCβ2⁺ and Car4⁺ cells, as well as decreases in expression levels of taste transduction genes. Tmem59^-/- mice showed deficits i

SUBMITTER: Ren W 

PROVIDER: S-EPMC11634696 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature