Extracellular vesicle-encapsulated miR-30c-5p reduces aging-related liver fibrosis.

ABSTRACT: Aging is associated with decreased health span, and despite the recent advances made in understanding the mechanisms of aging, no antiaging drug has been approved for therapy. Therefore, strategies to promote a healthy life in aging are desirable. Previous work has shown that chronic treatment with extracellular vesicles (EVs) from young mice prolongs lifespan in old mice, but the mechanism of action of this effect on liver metabolism is not known. Here we investigated the role of treatment with EVs derived from young sedentary (EV-C) or exercised (EV-EX) mice in the metabolism of old mice and aimed to identify key youthful-associated microRNA (miRNA) cargos that could promote healthy liver function. We found that aged mice treated with either EV-C or EV-EX had higher insulin sensitivity,

SUBMITTER: Rodrigues AC 

PROVIDER: S-EPMC11634720 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature