Periodic protein-restricted diets extend the lifespan of high-fat diet-induced Drosophila melanogaster males.

ABSTRACT: Research has shown that sustained protein restriction can improve the effects of a high-fat diet on health and extend lifespan. However, long-term adherence to a protein-restricted diet is challenging. Therefore, we used a fly model to investigate whether periodic protein restriction (PPR) could also mitigate the potential adverse effects of a high-fat diet and extend healthy lifespan. Our study results showed that PPR reduced body weight, lipid levels, and oxidative stress induced by a high-fat diet in flies and significantly extended the healthy lifespan of male flies. Lipid metabolism and transcriptome results revealed that the common differences between the PPR group and the control group and high-fat group showed a significant decrease in palmitic acid in the PPR group; the enriched c

SUBMITTER: Wang R 

PROVIDER: S-EPMC11634745 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature