Adipose tissue retains an epigenetic memory of obesity after weight loss.

ABSTRACT: Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity^1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes^3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown. Here, by using single-nucleus RNA sequencing, we show that both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mi

SUBMITTER: Hinte LC 

PROVIDER: S-EPMC11634781 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature