Quantitative Imaging of Regional Cerebral Protein Synthesis in Clinical Alzheimer's Disease by [¹¹C]Leucine PET.

ABSTRACT:

Purpose

Protein synthesis is essential to maintain integrity and function of the human brain, and protein synthesis is associated specifically with the formation of long-term memory. Experimental and clinical observations indicate that this process is disturbed in Alzheimer's dementia and other neurodegenerative diseases. In-vivo investigation with positron emission tomography (PET) using [¹¹C]leucine provides a unique possibility to measure regional cerebral protein synthesis (rCPS) rates in human brain and to determine whether it is altered in Alzheimer's disease (AD), and thus may provide a target for future therapeutic interventions.

Procedures

In this first human study, we measured rCPS by [¹¹C]leucine PET in four patients with AD (age 57-73 years)

SUBMITTER: Herholz K 

PROVIDER: S-EPMC11634943 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature