Prospective Comparison of [¹⁸F]FDG and [¹⁸F]AIF-FAPI-74 PET/CT in the Evaluation of Potentially Resectable Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Purpose

Accurate clinical staging of potentially resectable pancreatic ductal adenocarcinoma (PDAC) is critical for establishing optimal treatment strategies. While the efficacy of fluorine-18-fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) in clinical staging is unclear, PET/CT detecting fibroblast-activation protein (FAP) expression has recently received considerable attention for detecting various tumors, including PDAC, with high sensitivity. We explored the efficacy of [¹⁸F]FDG and [¹⁸F]AIF-FAPI-74 PET/CT in the initial evaluation of potentially resectable PDAC.

Procedures

Between 2021 and 2022, twenty participants with newly diagnosed potentially resectable PDAC were enrolled. After the initial ev

SUBMITTER: Yun WG 

PROVIDER: S-EPMC11634952 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature