Humoral correlates of protection against <i>Mycobacterium tuberculosis</i> following intravenous BCG vaccination in rhesus macaques.

ABSTRACT: Altering Bacille Calmette-Guérin (BCG) immunization from low-dose intradermal (i.d.) to high-dose intravenous (i.v.) vaccination provides a high level of protection against Mycobacterium tuberculosis (Mtb). In addition to strong T cell immunity, i.v. BCG drives robust humoral immune responses that track with bacterial control. However, given the near-complete protection afforded by high-dose i.v. BCG immunization, a precise correlate of protection was difficult to define. Here we leveraged plasma and bronchoalveolar lavage fluid (BAL) from a cohort of rhesus macaques that received decreasing doses of i.v. BCG and aimed to define correlates of immunity following Mtb challenge. We show an i.v. BCG dose-dependent induction of mycobacterial-specific humoral immune response

SUBMITTER: Irvine EB 

PROVIDER: S-EPMC11634979 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature