Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice.

ABSTRACT: Patients receiving cranial radiation therapy experience tissue damage and cognitive deficits that severely decrease their quality of life. Experiments in rodent models show that these adverse neurological effects are in part due to functional changes in microglia, the resident immune cells of the central nervous system. Increasing evidence suggests that experimental manipulation of microglial signaling can regulate radiation-induced changes in the brain and behavior. Furthermore, many studies show sex-dependent neurological effects of radiation exposure. Despite this, few studies have used both males and females to explore how sex and microglial function interact to influence radiation effects on the brain. Here, we used a system levels approach to examine how deficiencies in purinergic an

SUBMITTER: Strohm AO 

PROVIDER: S-EPMC11634995 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature