Hyperpolarized [1-¹³C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure.

ABSTRACT:

Background

Hyperpolarized [1-¹³C]pyruvate cardiovascular magnetic resonance imaging (HP [1-¹³C]pyruvate CMR) visualizes key steps in myocardial metabolism. The present study aimed to examine patients with heart failure (HF) using HP [1-¹³C]pyruvate CMR.

Methods

A cross-sectional study of patients with HF and healthy controls using HP [1-¹³C]pyruvate CMR. Metabolic imaging was obtained using a cardiac-gated spectral-spatial excitation with spiral read-out acquisition. The metabolite signal was analyzed for lactate, bicarbonate, and the alanine signal. Metabolite signal was normalized to the total carbon signal (TC). At the 1-year follow-up, echocardiography was performed in all patients and HP [1-¹³C]pyruvate MRI in two p

SUBMITTER: Joergensen SH 

PROVIDER: S-EPMC11635003 | biostudies-literature | 2024 Winter

REPOSITORIES: biostudies-literature