Combining developmental and sleep health measures for autism spectrum disorder screening: an ECHO study.

ABSTRACT:

Background

Sleep problems are reported for up to 80% of autistic individuals. We examined whether parsimonious sets of items derived from the Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) and the Brief Infant Sleep Questionnaire (BISQ) are superior to the standard M-CHAT-R in predicting subsequent autism spectrum disorder (ASD) diagnoses.

Methods

Participants from 11 Environmental influences on Child Health Outcomes (ECHO) cohorts were included. We performed logistic LASSO regression models with 10-fold cross-validation to identify whether a combination of items derived from the M-CHAT-R and BISQ are superior to the standard M-CHAT-R in predicting ASD diagnoses.

Results

The final sample comprised 1552 children. The standard M-CHAT-R had a sensitivity o

SUBMITTER: Shuffrey LC 

PROVIDER: S-EPMC11635013 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature