Development of a homotrimeric PSMA radioligand based on the NOTI chelating platform.

ABSTRACT:

Background

The NOTI chelating scaffold can readily be derivatized for bioconjugation without impacting its metal complexation/radiolabeling properties making it an attractive building block for the development of multimeric/-valent radiopharmaceuticals. The objective of the study was to further explore the potential of the NOTI chelating platform by preparing and characterizing homotrimeric PSMA radioconjugates in order to identify a suitable candidate for clinical translation.

Results

Altogether, three PSMA conjugates based on the NOTI-TVA scaffold with different spacer entities between the chelating unit and the Glu-CO-Lys PSMA binding motif were readily prepared by solid phase-peptide chemistry. Cell experiments allowed the identification of the homotrimeric conjugate 9 c

SUBMITTER: Martin S 

PROVIDER: S-EPMC11635053 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature