Incidence Rate and Predictors of Intracranial Hemorrhage in Patients With Atrial Fibrillation: A Report From the Nationwide COOL-AF Registry.

ABSTRACT:

Background

Specific risk predictor scores of intracranial hemorrhage (ICH) risk in Asian subjects are lacking. We determined the incidence rate and predictors of ICH in patients with non-valvular atrial fibrillation (AF).

Methods

A prospective nationwide registry of patients with AF was conducted from 27 hospitals in Thailand. The adjudicated primary outcome was the development of ICH during follow-up. Multivariable Cox proportional hazard model was performed to identify the independent predictors for ICH. A predictive model for ICH risk was developed and validated by bootstrap, calibration plot, C-statistics, and decision curve analysis using our own data.

Results

We studied a total of 3405 patients (mean age 67.8 years; 58.2% male) with an average follow-up duration

SUBMITTER: Krittayaphong R 

PROVIDER: S-EPMC11635119 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature