The Road to a Realistic 3D Model for Estimating R₂ and R₂* Relaxation Versus Gd-DTPA Concentration in Whole Blood and Brain Tumor Vasculature.

ABSTRACT: Dynamic susceptibility contrast (DSC) MRI is commonly part of brain tumor imaging. For quantitative analysis, measurement of the arterial input function and tissue concentration time curve is required. Usually, a linear relationship between the MR signal changes and contrast agent concentration ([Gd]) is assumed, even though this is a known simplification. The aim of this study was to develop a realistic 3D simulation model as an efficient method to assess the relationship between ΔR₂ ^(*) and [Gd] both in whole blood and brain tissue. We modified an open-source 3D simulation model to study different red blood cell configurations for assessing whole-blood ΔR₂ ^(*) versus [Gd]. The results were validated against previously obtained 2D data and in vi

SUBMITTER: van Dorth D 

PROVIDER: S-EPMC11635185 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature