Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study.

ABSTRACT:

Background

Platelet transfusions are given to preterm infants with severe thrombocytopenia aiming to prevent haemorrhage. The PlaNeT2/MATISSE trial revealed higher rates of mortality and/or major bleeding in preterm infants receiving prophylactic platelet transfusions at a platelet count threshold of 50 × 10⁹/L compared to 25 × 10⁹/L. The extent to which this evidence has been incorporated into clinical practice is unknown, thus we aimed to describe current neonatal platelet transfusion practices in Europe.

Methods

We performed a prospective observational study in 64 neonatal intensive care units across 22 European countries between September 2022 and August 2023. Outcome measures included observed transfusion prevalence rates (per country and overall,

SUBMITTER: Houben NAM 

PROVIDER: S-EPMC11635195 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature