Prognostic value of ubiquitination-related differentially expressed genes in esophageal squamous cell carcinoma: a comprehensive analysis and future directions.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) represents a considerable health challenge, primarily due to its poor prognosis and the limited availability of effective therapeutic interventions. Ubiquitination, a vital post-translational modification, is integral to cellular regulation; nonetheless, its role in ESCC has not been thoroughly explored. This study aims to identify ubiquitination-related differentially expressed genes (URDEGs) that possess prognostic significance in the context of ESCC.

Methods

We conducted a comprehensive analysis using The Cancer Genome Atlas ESCC (TCGA-ESCC) dataset, GSE20347, and an in-house ESCC dataset to identify URDEGs. The limma R package was used to determine the intersection of ubiquitination-related genes (URGs) with common dif

SUBMITTER: Chen J 

PROVIDER: S-EPMC11635202 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature