Investigation of pure lung microbiota in patients with lung cancer after eliminating upper airway contamination: a prospective cohort study.

ABSTRACT:

Background

While the relationship between gut microbiota and gastrointestinal cancer has been elucidated, the relationship between lung microbiota and lung cancer remains unclear. Previous study findings are inconclusive due to the possibility of contamination by upper airway microbiota in samples obtained from the oropharynx, such as saliva and sputum, and bronchoalveolar lavage fluid (BALF) collected during bronchoscopy. Therefore, this study aimed to detect pure lung microbiota in patients with lung cancer using BALF samples from resected lung specimens. Additionally, we aimed to evaluate the lung microbiota to clarify their relationship with lung cancer and aid in postoperative pneumonia (POP) prevention and treatment.

Methods

This prospective cohort study enrolled patie

SUBMITTER: Koyama T 

PROVIDER: S-EPMC11635203 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature