Establishment and validation of a prognostic model for idiopathic pulmonary fibrosis based on mitochondrial-related genes.

ABSTRACT:

Background

The prognosis for patients diagnosed with idiopathic pulmonary fibrosis (IPF) is exceedingly grim, and there are currently no pharmacological interventions available that effectively reduce mortality rates. Emerging evidence underscores the intimate connection between mitochondrial dysfunction and the onset and advancement of IPF. However, there remains a scarcity of prognostic models for assessing the risk associated with mitochondrial-related genes in IPF. This study aims to develop a comprehensive prognostic model for IPF that incorporates mitochondrial-related genes to enhance risk assessment and guide clinical decision-making.

Methods

Two IPF-related microarray expression profiling datasets (GSE28042 and GSE70866) accompanied with survival data were acquired

SUBMITTER: Wang X 

PROVIDER: S-EPMC11635208 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature