Farnesoid X receptor (FXR) as a potential therapeutic target for lung diseases: a narrative review.

ABSTRACT:

Background and objective

Farnesoid X receptor (FXR), which is encoded by the NR1H4 gene, is a ligand-activated transcription factor and a member of the nuclear receptor (NR) superfamily. As a receptor for bile acid (BA), FXR has been shown to play a key role in the regulation of BA metabolism, lipid metabolism, and the inflammatory response. This article reviews the roles of FXR in the pathogenesis of various lung diseases, and identifies potential diagnostic indicators or therapeutic targets for these diseases.

Methods

The PubMed and National Center for Biotechnology Information (NCBI) online databases were searched to retrieve relevant articles published from 2000 to 2024.

Key content and findings

FXR was originally found to be expressed in BA-targeted organs

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11635231 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature