Transcriptome sequencing analysis reveals the molecular mechanism of sepsis-induced muscle atrophy.

ABSTRACT:

Background

Sepsis-induced skeletal muscle atrophy is accompanied by complex physiological and biochemical changes that negatively affect clinical outcomes, lead to prolonged hospitalization, and even increase mortality. However, few studies have been performed on the mechanisms of the disease, and effective treatments are still lacking. This study is aimed to research the molecular mechanisms of sepsis-induced skeletal muscle atrophy and to develop new therapeutic strategies.

Methods

In this study, we first constructed a mouse model of sepsis after cecal ligation and puncture (CLP). At 12, 24, 48, and 72 hours after modeling, we then analyzed the differentially expressed genes (DEGs) in the tibialis anterior muscle using transcriptome sequencing technology.

Results

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SUBMITTER: Yan D 

PROVIDER: S-EPMC11635243 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature