Combined pulmonary fibrosis and emphysema and lung transplantation: current evidence and future directions.

ABSTRACT:

Background

Combined pulmonary fibrosis and emphysema (CPFE) patients generally have a poorer prognosis compared to those with either pulmonary fibrosis or chronic obstructive pulmonary disease (COPD)/emphysema alone, as demonstrated by several studies. Our study aimed to identify undiagnosed CPFE cases within a lung transplantation cohort initially diagnosed with interstitial lung fibrosis or COPD/emphysema. It was hypothesized that the patient cohort might contain overlooked CPFE cases, and CPFE patients would exhibit a higher incidence of pre-transplant pulmonary hypertension and post-transplant chronic lung allograft dysfunction (CLAD).

Methods

This is a single-center, retrospective cohort study conducted at the University Hospital of Zurich, Switzerland. Expert review of

SUBMITTER: Hage R 

PROVIDER: S-EPMC11635263 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature