Synthesis of 2<i>H</i>-azirine-2,2-dicarboxylic acids and their derivatives.

ABSTRACT: Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl₂-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by their reaction with nucleophiles are reported. Two approaches to the preparation of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides have been developed.

SUBMITTER: Agafonova AV 

PROVIDER: S-EPMC11635289 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature